2,4-dichloropyrimidine-5-carbaldehyde oxime
5-Pyrimidinecarboxaldehyde, 2,4-dichloro-
CAS: 871254-61-4
Molecular Formula: C5H2Cl2N2O
2,4-dichloropyrimidine-5-carbaldehyde oxime - Names and Identifiers
2,4-dichloropyrimidine-5-carbaldehyde oxime - Physico-chemical Properties
| Molecular Formula | C5H2Cl2N2O |
| Molar Mass | 176.99 |
| Density | 1.588±0.06 g/cm3(Predicted) |
| Boling Point | 294.0±20.0 °C(Predicted) |
| pKa | -4.44±0.29(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Use | Introduction 2, 4-dichloro-5-pyrimidine formaldehyde is a white solid liquid, which can continue to react to generate 2, 3-dichloro-5-cyanopyrimidine, the aldehyde group can be oxidized to generate carboxylic acid, 2,4-The chlorine at the position can undergo a nucleophilic substitution reaction to generate pyrimidine derivatives. |
2,4-dichloropyrimidine-5-carbaldehyde oxime - Preparation
in the reaction bottle, add solvent DMF(336mL), cool down to -5 ℃, slowly add phosphorus oxychloride (153g) dropwise, control the reaction temperature of the mixed system to no more than 5 ℃, add phosphorus oxychloride dropwise, add aluminum trichloride (66.7g), stir for 30min, then add 112g(1mol) of uracil in solid form to the mixed system in batches, and control the reaction temperature not to exceed 5 ℃, after stirring for 2 hours, slowly raise the temperature to room temperature and continue stirring until the raw materials disappear. Then add 1120mL of phosphorus oxychloride to the reaction system and raise the temperature to reflux reaction for 5h, then evaporate the recovered phosphorus oxychloride, the residue is poured into the rapidly stirred ice-water mixture, and 2, 4-dichloro-5-pyrimidine formaldehyde solid 150g is precipitated, with a yield of 85.2%.
Last Update：2024-04-10 22:29:15
2,4-dichloropyrimidine-5-carbaldehyde oxime - Reference Information
| introduction | 2,4-dichloro-5-pyrimidine formaldehyde is a white solid liquid, which can continue to react to generate 2, 3-dichloro-5-cyanopyrimidine, aldehyde group can be oxidized to generate carboxylic acid, 2, chlorine at the 4-position can undergo nucleophilic substitution reaction to form pyrimidine derivatives. |
| preparation | in the reaction bottle, add solvent DMF(336mL), cool to -5 ℃, slowly add phosphorus oxychloride (153g) dropwise, control the reaction temperature of the mixture system to no more than 5 ℃, and the phosphorus oxychloride dropwise is completed, add aluminum trichloride (66.7g), stir for 30min, then add 112g(1mol) of uracil in solid form to the above mixed system in batches, control the reaction temperature not to exceed 5 ℃, stir 2h, slowly raise the temperature to room temperature and continue stirring until the raw materials disappear. Then add phosphorus oxychloride 1120mL to the reaction system and raise the temperature to reflux reaction for 5h, then evaporate the recovered phosphorus oxychloride, the residue is poured into the rapidly stirred ice-water mixture, and 150g of 2,4-dichloro -5-pyrimidine formaldehyde solid is precipitated, with a yield of 85.2%. |
Last Update：2024-04-09 20:52:54
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